How does a high work
Cannabis gets you high primarily due to the interaction between its active compounds, particularly delta-9-tetrahydrocannabinol (THC), and the endocannabinoid system (ECS) in your body. Here's how it works:
1. **THC and Cannabinoid Receptors:** THC is the primary psychoactive compound in cannabis. When you consume cannabis, whether by smoking, vaping, or eating edibles, THC enters your bloodstream and travels to various parts of your body, including your brain.
2. **The Endocannabinoid System (ECS):** Your body has an endocannabinoid system, which consists of cannabinoid receptors (CB1 and CB2 receptors), endocannabinoids (naturally occurring compounds in your body), and enzymes that help regulate the system. CB1 receptors are mainly found in the brain and central nervous system.
3. **Binding to CB1 Receptors:** THC has a similar structure to the endocannabinoid anandamide, which is naturally produced in your body. Because of this similarity, THC can bind to and activate CB1 receptors in your brain and central nervous system.
4. **Altered Brain Activity:** When THC binds to CB1 receptors, it alters the activity of neurons in various parts of your brain, particularly in areas associated with mood, memory, perception, and coordination. This leads to the characteristic "high" associated with cannabis use.
- **Euphoria and Relaxation:** THC can stimulate the release of dopamine, a neurotransmitter associated with pleasure and reward, leading to feelings of euphoria and relaxation.
- **Changes in Perception:** THC can affect your sensory perception, making colors appear more vivid, sounds more pronounced, and taste and smell more intense.
- **Time Distortion:** Many cannabis users report a sense of time distortion, where minutes can feel like hours.
- **Increased Appetite:** THC can stimulate the appetite, often referred to as "the munchies."
- **Impaired Coordination:** THC can impair motor skills and coordination, which can lead to decreased reaction time and impaired driving ability.
5. **Varied Effects:** The effects of cannabis can vary widely from person to person and depend on factors like the dose of THC consumed, the individual's tolerance, and the specific strain of cannabis used. Different strains may have different effects, with some being more relaxing (indica-dominant) and others more energizing (sativa-dominant).
It's important to note that while THC is the primary psychoactive compound in cannabis, there are many other cannabinoids and terpenes in the plant that can also influence the overall effects and experience. Additionally, the way cannabis is consumed (e.g., smoking, vaping, edibles) can impact the onset and duration of the high. Responsible and moderate use of cannabis is essential to ensure a safe and enjoyable experience.
